Last update
4/4/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Selenium (as L-selenomethionine)
100 mcg
182%
Top Medical Research Studies
8
We studied how selenium-polysaccharides (Se-TP) from green tea could improve chronic fatigue syndrome (CFS) in a rat model. Our experiments revealed that Se-TP significantly enhanced levels of certain substances related to fatigue, indicating improved overall condition. However, while the treatment showed promise in restoring some metabolic markers, the overall efficacy in CFS management remains to be fully affirmed. The changes observed were tied to metabolic pathways involved in steroid hormone biosynthesis and other critical processes.
Read More
8
We explored how sweet corn cob polysaccharide selenium nanoparticles (U-SCPSeNPs) might help alleviate symptoms of chronic fatigue syndrome (CFS). In this study, we used mouse models to test the effects of these nanoparticles, which were created using an ultrasound-assisted method.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
Read More
7
CoQ10 and selenium may benefit ME/CFS
We explored whether combining Coenzyme Q10 and selenium could improve outcomes for individuals with chronic fatigue syndrome (ME/CFS). In this study, 27 patients took an oral supplement for 8 weeks. While we noted improvements in overall fatigue severity and quality of life, sleep disturbances did not show any significant change. Additionally, we found increased antioxidant capacity and decreased inflammatory markers, indicating potential benefits. However, other key biomarkers did not show significant changes. Overall, this suggests that long-term supplementation might help some symptoms in ME/CFS.
Read More
Most Useful Reviews
9
Long-lasting relief
Since taking selenium, I have experienced an extended period without fatigue.
Read More
7.5
Eliminates fatigue
Selenium is a trace element that plays crucial roles in the body, including antioxidant effects, immune support, regulation of the thyroid gland, and enhancement of reproductive function. It effectively alleviates fatigue symptoms. However, it is required in very small quantities, so dosage must be monitored carefully. This supplement contains 100 μg of yeast-free L-selenomethionine, a form that the body easily absorbs, making it highly bioavailable. It has a neutral taste and is of average size, with a recommended daily intake. Advantages include price, composition, quality, and the use of natural ingredients, which provide essential minerals. The large packaging ensures sufficient supply to correct any deficiencies.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
We explored how sweet corn cob polysaccharide selenium nanoparticles (U-SCPSeNPs) might help alleviate symptoms of chronic fatigue syndrome (CFS). In this study, we used mouse models to test the effects of these nanoparticles, which were created using an ultrasound-assisted method.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
Read More
8
We studied how selenium-polysaccharides (Se-TP) from green tea could improve chronic fatigue syndrome (CFS) in a rat model. Our experiments revealed that Se-TP significantly enhanced levels of certain substances related to fatigue, indicating improved overall condition. However, while the treatment showed promise in restoring some metabolic markers, the overall efficacy in CFS management remains to be fully affirmed. The changes observed were tied to metabolic pathways involved in steroid hormone biosynthesis and other critical processes.
Read More
7
CoQ10 and selenium may benefit ME/CFS
We explored whether combining Coenzyme Q10 and selenium could improve outcomes for individuals with chronic fatigue syndrome (ME/CFS). In this study, 27 patients took an oral supplement for 8 weeks. While we noted improvements in overall fatigue severity and quality of life, sleep disturbances did not show any significant change. Additionally, we found increased antioxidant capacity and decreased inflammatory markers, indicating potential benefits. However, other key biomarkers did not show significant changes. Overall, this suggests that long-term supplementation might help some symptoms in ME/CFS.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Long-lasting relief
Since taking selenium, I have experienced an extended period without fatigue.
Read More
7.5
Eliminates fatigue
Selenium is a trace element that plays crucial roles in the body, including antioxidant effects, immune support, regulation of the thyroid gland, and enhancement of reproductive function. It effectively alleviates fatigue symptoms. However, it is required in very small quantities, so dosage must be monitored carefully. This supplement contains 100 μg of yeast-free L-selenomethionine, a form that the body easily absorbs, making it highly bioavailable. It has a neutral taste and is of average size, with a recommended daily intake. Advantages include price, composition, quality, and the use of natural ingredients, which provide essential minerals. The large packaging ensures sufficient supply to correct any deficiencies.
Read More
Frequently Asked Questions
9
Long-lasting relief
Since taking selenium, I have experienced an extended period without fatigue.
7.5
Eliminates fatigue
Selenium is a trace element that plays crucial roles in the body, including antioxidant effects, immune support, regulation of the thyroid gland, and enhancement of reproductive function. It effectively alleviates fatigue symptoms. However, it is required in very small quantities, so dosage must be monitored carefully. This supplement contains 100 μg of yeast-free L-selenomethionine, a form that the body easily absorbs, making it highly bioavailable. It has a neutral taste and is of average size, with a recommended daily intake. Advantages include price, composition, quality, and the use of natural ingredients, which provide essential minerals. The large packaging ensures sufficient supply to correct any deficiencies.
8
We explored how sweet corn cob polysaccharide selenium nanoparticles (U-SCPSeNPs) might help alleviate symptoms of chronic fatigue syndrome (CFS). In this study, we used mouse models to test the effects of these nanoparticles, which were created using an ultrasound-assisted method.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
7
CoQ10 and selenium may benefit ME/CFS
We explored whether combining Coenzyme Q10 and selenium could improve outcomes for individuals with chronic fatigue syndrome (ME/CFS). In this study, 27 patients took an oral supplement for 8 weeks. While we noted improvements in overall fatigue severity and quality of life, sleep disturbances did not show any significant change. Additionally, we found increased antioxidant capacity and decreased inflammatory markers, indicating potential benefits. However, other key biomarkers did not show significant changes. Overall, this suggests that long-term supplementation might help some symptoms in ME/CFS.
8
We studied how selenium-polysaccharides (Se-TP) from green tea could improve chronic fatigue syndrome (CFS) in a rat model. Our experiments revealed that Se-TP significantly enhanced levels of certain substances related to fatigue, indicating improved overall condition. However, while the treatment showed promise in restoring some metabolic markers, the overall efficacy in CFS management remains to be fully affirmed. The changes observed were tied to metabolic pathways involved in steroid hormone biosynthesis and other critical processes.
References
- Wang J, Wang X, Xiu W, Li C, Yu S, et al. Ultrasound-assisted preparation of sweet corn cob polysaccharide selenium nanoparticles alleviates symptoms of chronic fatigue syndrome. Food Funct. 2025;16:133. 10.1039/d4fo04195j
- Castro-Marrero J, Domingo JC, Cordobilla B, Ferrer R, Giralt M, et al. Does Coenzyme Q10 Plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?. Antioxid Redox Signal. 2022;36:729. 10.1089/ars.2022.0018
- Shao C, Song J, Zhao S, Jiang H, Wang B, et al. Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Green Tea on Chronic Fatigue Syndrome. Polymers (Basel). 2018;10. 10.3390/polym10111269
